The National Network to Innovate for COVID-19 and Adult Vaccine Equity (NNICE) is a partnership of Michigan State University, Michigan Public Health Institute, the Community Foundation of Greater Flint and Community Campus Partnerships for Health. These organizations reflect the ‘pillars’ for a network of organizations that represent four important sectors of society, including: 1) academic institutions; 2) the national network of Public Health Institutes that support public health practice and translation; 3) local community foundations/philanthropy (whose legacy and mission is to lead local fund raising, grant-making and sustainability efforts); and 4) grass roots community organizations. The bringing together of these four pillars to form a network of partners to mitigate the disparate impact of COVID-19 and boost confidence in and receipt of COVID-19 and other adult vaccinations, is timely and relevant to the current pandemic and adult vaccine disparities and inequities more broadly in the nation.